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Dynamically Crosslinked Gold Nanoparticle – Hyaluronan Hydrogels

Aleksander Skardal, Jianxing Zhang, Lindsi McCoard, Siam Oottamasathien, Glenn D. Prestwich


Bioprinting consists of automated deposition of cells and biomaterials to mimic the architecture of a tissue. Gold nanoparticles act as dynamic, multivalent crosslinkers for thiol‐modified hyaluronic acid and gelatin. The resulting synthetic extracellular matrix can be bioprinted into tubular constructs that support cell proliferation and matrix remodeling. The figure shows a view of a tissue construct (containing a fluorescent dye) in the x‐y plane, and the inset shows the print head used.


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