In the body, cells reside and operate in the extracellular matrix (ECM), which is a structural scaffold comprised of glycoproteins, polysaccharides, and proteoglycans. It provides a physical support to tissues, but also serves as a complex reservoir of binding ligands and signaling molecules that drive a wide range of biological functions of tissue cells.
MxDx Bio employs ECM-derived biomaterials as the core technology that support cells in the organoid and organ-on-a-chip portfolio. One strategy is the use of decellularized or reconstituted ECM from native tissues, thus maintaining the majority of structural and biochemical factors of a given tissue type. This is a comprehensive platform that best mimics the complexity of the ECM in vivo.
A second strategy is engineering the ECM from the ground up in a modular fashion. This approach employs only a small number of ECM components, but chooses to use a stripped down, and well-defined formulation for increased acceptability in applications subject to regulatory approval.
3D bioprinting has advanced rapidly in the past decade. However, the interactions between the biomaterials (aka, bioinks), the bioprinting hardware, and the cells that populate the bioinks are still poorly understood.
Previous biomaterials were not optimized for the dynamic events encountered during bioprinting. MxDx Bio’s bioprinting technology incorporates novel biomaterials with advanced, stimulus-responsive mechanical properties, facilitating deployment on most bioprinter platforms, enabling biomanufacturing of organoids for in vitro drug evaluation. A biomimetic formulation, inspired by biology, allows for customization with cell-recognized proteins, but in a defined manner, suitable for clinical applications.