In the body, cells reside and operate in the extracellular matrix (ECM), which is a structural scaffold comprised of glycoproteins, polysaccharides, and proteoglycans. It provides a physical support to the tissues, but also serves as a complex reservoir of binding ligands and signaling molecules that drive a wide range of biological functions of tissue cells.
MxDx Bio employs ECM-derived biomaterials as the core technology that support cells in the organoid and organ-on-a-chip portfolio. One strategy is the use of decellularized or reconstituted ECM from native tissues, thus maintaining the majority of structural and biochemical factors of a given tissue type. This is a comprehensive platform that best mimics the complexity of the ECM in vivo.
Extracellular matrix biomaterials:
- Tissue Matrix Scaffold (TMS)
- ECM Hydrogels
- Supports cell-laden in vivo implantation
- Customized shapes or sizes are possible
Biomarker, Drug, and toxicological screening:
- Biomedical research and novel biomarker discoveries
- Pharmacological drug and toxicological screening
- Clinical diagnostic and prognostic screening
- Personalized and precision medicine
- 3D bioprinting has advanced rapidly since its inception, particularly with respect to hardware platforms, yet much less attention has been paid to understanding the interactions between the biomaterials, or bioinks, with the bioprinting hardware and the cells that populate bioinks.
In vitro disease models:
- The culmination of MxDx Bio technology portfolio is a versatile platform comprised of in vitro and
ex vivo disease models, including 3D organoids and organ-on-a-chip systems.
Built By Researchers
MxDx Bio aims to provide its unique proprietary technologies and mproducts to its customers. The platforms we developed are derived from native tissue ECM at total or select component levels that closely mimics natural tissues microenvironment for biomedical and bioengineering applications.
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